Search results for "Icu patients"
showing 5 items of 5 documents
The use of proton pump inhibitors in an Italian hospital: focus on oncologic and critical non-ICU patients
2015
Background Proton pump inhibitors (PPIs) are among the most misused drugs both at the community and hospital level. Recently, possible risks have been underscored, suggesting the importance of limiting PPI use to proven indications. Objective To survey the appropriateness of PPI use in a University hospital in Italy. Setting Azienda Ospedaliera Universitaria Policlinico ‘P. Giaccone’, in Palermo, Italy. Method A one day-observational study, reviewing patients’ medical records to identify treatments with PPIs and the indications for their use. After discharge, a subgroup of the cohort was followed up to assess the continuation of therapy at home. Appropriateness was evaluated according to th…
Choosing the Right Antifungal Agent in ICU Patients
2019
Fungi are responsible for around 20% of microbiologically documented infections in intensive care units (ICU). In the last decade, the incidence of invasive fungal infections (IFI), including candidemia, has increased steadily because of increased numbers of both immunocompromised and ICU patients. To improve the outcomes of patients with IFI, intensivists need to be aware of the inherent challenges. This narrative review summarizes the features of routinely used treatments directed against IFI in non-neutropenic ICU patients, which include three classes of antifungals: polyenes, azoles, and echinocandins. ICU patients' pathophysiological changes are responsible for deep changes in the phar…
EMPHASIZING MULTIPROFESSIONAL COLLABORATION TO MEET THE ICU PATIENTS NUTRITION NEEDS
2015
Many studies have shown that the standard of the nutrition of ICU-patients influence the patient results, measured by ICU-LOS (length of stay), hospital-LOS and mortality. The energy deficit accumulating during the first days of the ICU stay may play an important role for the patient results. After implementation of a multi-professional ICU nutrition protocol, including a broadly teaching/information phase for both nurses and anesthesiologists, we conducted a retrospective study.
Two optimizing procedures for the solution of complex systems of equations: a powerful tool for modelling and simulation of metabolism
2000
Introduction Standard calculations for the evaluation of indirect calorimetry (IC) are based on two-dimensional nonlinear systems of equations. For a more sophisticated evaluation metabolic models can be used, which are described by complex systems of equations. Since the solutions are multidimensional, a concrete result must be selected by means of constraints, using optimizing procedures. These multidimensional optimizations are critical concerning processing time and reproducibility of minimum detection. Methods In order to simulate the status of metabolism of ICU patients on the basis of IC data, a complex model of metabolism was developed. The model was described by a system of equatio…
Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with external ventricular drain
2018
International audience; Background: Due to its antibacterial properties ceftaroline could be attractive for the treatment of bacterial postneurosurgicalmeningitis. However only few data are available concerning its meningeal concentrations. The aim of this studywas to investigate ceftaroline cerebrospinal fluid (CSF) pharmacokinetics (PK) in intensive care unit (ICU) patients with anexternal ventricular drain (EVD).Materials/methods: Patients received a single 600 mg dose of ceftaroline as a one-hour intravenous infusion . Blood and CSFsamples were collected before and 0.5, 1, 3, 6, 12 and 24 hours after the end of the infusion. Concentrations were assayed inplasma and CSF by LC-MS/MS. A tw…